Anti-ageing tripeptide that mimics the activity found in snake venom


Reduces the appearance of wrinkles. Fast acting, long lasting and fully reversable

INCI name: 

Dipeptide Diaminobutyroyl Benzylamide Diacetate


  • DSM

For expression lines.

SYN®-AKE is a synthetic peptide that provides a safe and effective alternative to “Botox” in the treatment of facial expression lines.

Inspiration for SYN®-AKE came from an active component in the venom of the temple viper, in its ability to inhibit muscle contractions. DSM created a synthetic peptide that mimics this property of the venom, and which is able to quickly and safely reduce the facial muscle contraction in a completely reversible manner, without the need for costly injections or clinical procedures.

In-vivo studies on crow’s feet lines and forehead wrinkles demonstrates excellent skin smoothing and anti-wrinkle effects when compared to placebo and competitor peptides.

New in-vivo clinical studies on different age groups suggests that SYN®-AKE can:

  • Help your face relax without losing the ability to express yourself.
  • Visibly reduces deep wrinkles by up to 20%  in just 4 weeks.
  • Helps delay the appearance of wrinkles with "age-freezing" effects.
  • Delay the appearance of mimic wrinkles by up to 5 years.

It is supplied as a PEG-free and preservative-free aqueous solution and is easy to formulate into most cosmetic bases.

For a more detailed explanation of DSM's SYN® Peptide technology please click here.